Luxembourg Institute of Health (LIH)

Address 1A-B rue Thomas Edison
L-1445 Strassen
Luxembourg
Platforms ATMP & Biological, Biomarkers, Vaccines
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The Luxembourg Institute of Health is a public biomedical research organisation. Striving for excellence, its researchers, by their creativity, enthusiasm and commitment, generate knowledge on disease mechanisms and contribute to the development of new diagnostics, innovative therapies and clinical applications that impact the healthcare of Luxembourgish and European citizens.

At the forefront of biomedical sciences, the Luxembourg Institute of Health is deeply involved in implementing national and international research programs in personalized medicine. It acts as a catalyst for promoting research collaborations with healthcare providers, hospitals and other public and private biomedical organisations. To create economic and societal value, it purposes the translation of its scientific discoveries and technological developments. As the first supplier of public health information in Luxembourg, it also enables public authorities to make decisions based on scientific data and to communicate validated data to international institutions.

LIH is comitted to the investigation of Translational Health, Preventive Medicine and Digital Health.

LIH has the following translational structures and platforms:

  1.  The Transversal Translational Medicine (TTM) group  -> Discover more
  2. Translational Medicine Operations Hub (TMOH):
    1. Integrated BioBank of Luxembourg (IBBL), EATRIS institute -> Discover more
    2. Clinical and Epidemiological Investigation Center (CIEC) -> Discover more
    3. Luxembourg Clinical and Translational Research Center (LCTR) -> Discover more
  3. LIH Bioinformatics platform -> Discover more
  4. National Cytometry platform (NCP)
  5. Animal facility:
    1. In Vivo Imaging -> Discover more
  6. Personalized Functional Profiling  (PFP) -> Discover more
  7. Digital Medicine Group -> Discover more
  8. Data Integration and Analysis Unit (DIA)

The Luxembourg Institute of Health hosts a large number of trainees, Master students and PhD candidates, affiliated to the University of Luxembourg or to foreign partner universities, as well as postdoctoral scientists specialising themselves in a given research domain. Modern infrastructure, state-of-the-art technologies and a stimulating work environment, guaranteeing quality supervision and training, are provided to these young scientists starting their career.

As such LIH is currently coordinating a doctoral training unit (DTU) of 20 Ph.D positions, called i2TRON (integrating immune strategies in Translational Research in Oncology and Neurology). The aim of i2TRON is to train next generation translational scientists in order to advance research innovations focusing on immunological components across model diseases, and to turn new mechanistic insight into diagnostic and therapeutic strategies to improve patient care.

LIH is a partner in the CoVaLux (COVID-19, Vaccination & Long-term health consequences of COVID-19 in Luxembourg) study, which is a comprehensive research framework study aimed at addressing key unanswered questions related to COVID-19, focusing specifically on vaccination and on the long-term health impact of COVID-19.

Despite the worldwide COVID-19 pandemic entering its second year, open questions pertaining to the occurrence of new variants, ensuing new waves, vaccination effectiveness and immune responses remain to be elucidated.

In addition, more than 25,000 individuals in Luxembourg are estimated to be affected by Long COVID, an emerging long-term medical condition characterised by persisting COVID-19 related symptoms. All of these factors highlight the importance of looking at the pandemic from a broader perspective. The aim is to assess whether we need to optimise current strategies for prioritising vaccination in view Long COVID, while analysing the impact of vaccination on individual and population-level outcomes.

Contact

Facility National Cytometry Platform / Quantitative Biology Unit
Head of the facility
  • Antonio Cosma

Expertise

Technologies
  • MesoScale Discovery(MSD)
  • LC-MS
  • High resolution accurate mass spectrometry
  • Flow, Mass, Imaging cytometry
Purposes
  • Research
Applications
  • Biomarkers discovery and development
  • Disease processes research
  • Expression proteomics
  • Interaction proteomics and protein networks
  • Post-translational modifications
Certifications
  • ISO 9001

DATA ANALYSIS for

  • Proteomics
  • Flow, Mass and Image cytometry

DATA INTERPRETATION for

  • Proteomics
  • Flow, Mass and Image cytometry

STATISTICS

  • Molecular profiling (omics and others)
  • Expertise in clinical design of experiments, clinical statistics
  • Imaging
  • Metadata (patient/sample information)

BIOINFORMATICS

  • Proteins annotation
  • Expression profiling of omics and proteins
  • Expression profiling with PCRs
  • Data integration (“Systems biology”)
  • Bioinformatics tools: Qlucore Omics Explorer, Tableau Prep, Tableau Desktop

OMICS INTEGRATION METHODS

  • Proprietary tools (Mass spectrometry data processing software, R, Python, Tableau Prep and Tableau Desktop)

The activities of the Luxembourg Institute of Health are developed within the following research topics, also reflected in its department structure: Oncology, Infection and Immunity, Population Health.

Department of Infection and Immunity (DII)  aims to understand the complex mechanisms of infectious and inflammatory disease processes in order to enable new ways to diagnose, prevent or cure human diseases. Such a strategy requires the existence of a highly interdisciplinary research environment with intensive collaboration of basic and clinical immunologists, engineers, biochemists, computational and systems biologists, public health specialists and clinician scientists.     ->Discover more

Department of Cancer Research: Its vision is to execute world-class cancer research within certain prioritised areas based on strong intradepartmental scientific track records, and to provide research expertise covering the most common cancer types that represents a health problem in Luxembourg. The department also represents a state-of-the art training ground for next generation cancer researchers in Luxembourg, -and acts as a reference point for cancer research at the national level.      -> Discover more

The Department of Precision Health (DoPH) is an interdisciplinary research centre focusing on epidemiology and public health research across a wide range of areas including cardio-metabolic conditions, sports medicine, human bio-monitoring, health economics and clinical investigations. By the evidence we generate, we aim at tackling the major causes of morbidity and mortality, improving quality of life and informing clinical and public health guidelines in the country.    -> Discover more