Luxembourg Institute of Health (LIH)

Address 1A-B rue Thomas Edison
L-1445 Strassen
Luxembourg
Platforms ATMP & Biological, Biomarkers, Vaccines
Tags , , , , , ,

The Luxembourg Institute of Health is a public biomedical research organisation. Striving for excellence, its researchers, by their creativity, enthusiasm and commitment, generate knowledge on disease mechanisms and contribute to the development of new diagnostics, innovative therapies and clinical applications that impact the healthcare of Luxembourgish and European citizens.

At the forefront of biomedical sciences, the Luxembourg Institute of Health is deeply involved in implementing national and international research programs in personalized medicine. It acts as a catalyst for promoting research collaborations with healthcare providers, hospitals and other public and private biomedical organisations. To create economic and societal value, it purposes the translation of its scientific discoveries and technological developments. As the first supplier of public health information in Luxembourg, it also enables public authorities to make decisions based on scientific data and to communicate validated data to international institutions.

LIH has the following translational structures and platforms:

  1. The Transversal Translational Medicine (TTM) group  -> Discover more
  2. Luxembourg Clinical and Translational Research Center (LCTR)
  3. Translational Medicine Operations Hub (TMOH):
    1. Integrated BioBank of Luxembourg (IBBL), EATRIS institute -> Discover more
    2. Clinical and Epidemiological Investigation Center (CIEC) -> Discover more
    3. National Platform for Cytometry -> Discover more
    4. LuxGen platform -> Discover more
  4. LIH Bioinformatics platform -> Discover more
  5. Animal facility:
    1. In Vivo Imaging -> Discover more

Furthermore, LIH collaborates with many institutes and infrastructures across Luxembourg:

  1. Luxembourg Centre for Systems Biomedicine (LCSB),EATRIS institute -> Discover more
  2. Luxembourg Institute of Science and Technology (LIST) -> Discover more
  3. Luxembourg Institute of Socio-Economic Research (LISER) -> Discover more
  4. Hospital Center Luxembourg (CHL) -> Discover more
  5. Laboratoire National De Santé (LNS), collaboration partner for Luxgen -> Discover more
  6. Luxinnovation -> Discover more
  7. Personalised Medicine Consortium (PMC) -> Discover more
  8. Research Luxembourg -> Discover more

Together, the Luxembourgish public research environment supported the development and implementation of translational projects such as:

  1. COvid-19 National survey for assessing VIral spread by Non-affected CarriErs (CONVINCE) -> Discover more,
  2. Predicting the Severity of Covid-19 Infection study (Predi-COVID) -> Discover more
  3. The National Centre of Excellence in Research on Parkinson’s disease (NCER PD) -> Discover more
  4. Demence Prevention Program (PDP) -> Discover more
  5. integrating immune strategies in Translational Research in Oncology and Neurology (i2TRON) -> Discover more

The Luxembourg Institute of Health hosts a large number of trainees, Master students and PhD candidates, affiliated to the University of Luxembourg or to foreign partner universities, as well as postdoctoral scientists specialising themselves in a given research domain. Modern infrastructure, state-of-the-art technologies and a stimulating work environment, guaranteeing quality supervision and training, are provided to these young scientists starting their career.

As such LIH is currently coordinating a doctoral training unit (DTU) of 20 Ph.D positions, called i2TRON (integrating immune strategies in Translational Research in Oncology and Neurology). The aim of i2TRON is to train next generation translational scientists in order to advance research innovations focusing on immunological components across model diseases, and to turn new mechanistic insight into diagnostic and therapeutic strategies to improve patient care.

The activities of the Luxembourg Institute of Health are developed within the following research topics, also reflected in its department structure: Oncology, Infection and Immunity, Population Health.

Department of Infection and Immunity (DII)  aims to understand the complex mechanisms of infectious and inflammatory disease processes in order to enable new ways to diagnose, prevent or cure human diseases. Such a strategy requires the existence of a highly interdisciplinary research environment with intensive collaboration of basic and clinical immunologists, engineers, biochemists, computational and systems biologists, public health specialists and clinician scientists.     ->Discover more

Department of Oncology (DONC): Its vision is to execute world-class cancer research within certain prioritised areas based on strong intradepartmental scientific track records, and to provide research expertise covering the most common cancer types that represents a health problem in Luxembourg. The department also represents a state-of-the art training ground for next generation cancer researchers in Luxembourg, -and acts as a reference point for cancer research at the national level.      -> Discover more

The Department of Population Health (DoPH) is an interdisciplinary research centre focusing on epidemiology and public health research across a wide range of areas including cardio-metabolic conditions, sports medicine, human bio-monitoring, health economics and clinical investigations. By the evidence we generate, we aim at tackling the major causes of morbidity and mortality, improving quality of life and informing clinical and public health guidelines in the country.    -> Discover more

Contact

Facility National Cytometry Platform / Quantitative Biology Unit
Head of the facility
  • Antonio Cosma

Expertise

Technologies
  • MesoScale Discovery(MSD)
  • LC-MS
  • High resolution accurate mass spectrometry
  • Flow, Mass, Imaging cytometry
Purposes
  • Research
Applications
  • Biomarkers discovery and development
  • Disease processes research
  • Expression proteomics
  • Interaction proteomics and protein networks
  • Post-translational modifications

Features

Collaboration with industry where the institute collaborated with Proteomics expertise (in the last 5 years) <10
% of TIME involved in technology/methods development/innovation/intellectual property related to Proteomics 30%
Certifications
  • ISO 9001

Track record

Key opinion leaders
  • Antonio Cosma - expert in flow and mass cytometry
Publications

DATA ANALYSIS for

  • Proteomics
  • Flow, Mass and Image cytometry

DATA INTERPRETATION for

  • Proteomics
  • Flow, Mass and Image cytometry

STATISTICS

  • Molecular profiling (omics and others)
  • Expertise in clinical design of experiments, clinical statistics
  • Imaging
  • Metadata (patient/sample information)

BIOINFORMATICS

  • Proteins annotation
  • Expression profiling of omics and proteins
  • Expression profiling with PCRs
  • Data integration (“Systems biology”)
  • Bioinformatics tools: Qlucore Omics Explorer, Tableau Prep, Tableau Desktop

OMICS INTEGRATION METHODS

  • Proprietary tools (Mass spectrometry data processing software, R, Python, Tableau Prep and Tableau Desktop)