RECOGNISED – RETINAL AND COGNITIVE DYSFUNCTION IN TYPE 2 DIABETES

Project Acronym RECOGNISED
Funding Program Horizon 2020
Budget 5,998,273 EUR
Coordinator VHIR

About RECOGNISED

The four-year long RECOGNISED project will study the biological mechanisms that cause structural and functional alterations in the retina in people with type 2 diabetes (T2D) at risk of developing cognitive impairment and dementia. Based around the concept of the eye being a “window to the brain”, RECOGNISED will determine whether evaluating the retina, easily accessible with current non-invasive technologies, could help in identifying earlier cognitive impairment in people with T2D, so that appropriate support can be given.

In recent years there is mounting evidence that type 2 diabetes (T2D) is associated with cognitive impairment and dementia, which can be considered as a “new” long-term diabetic co-morbid complication with dramatic consequences for patients and their families and a significant impact for healthcare systems. At present there are no reported phenotypic indicators or reliable tests to identify T2D patients at risk of developing dementia. Since the retina is ontogenically a brain-derived tissue, we propose that the evaluation of retinal parameters related to either neurodegeneration or microvascular disease will be robust and valuable biomarkers to identify those T2D patients at higher risk of developing cognitive impairment and dementia.

On this basis the overarching aims of the project are:

1) To investigate the common mechanisms involved in the pathogenesis of DR and cognitive impairment in the T2D;

2) To use the retina as a tool to identifying individuals with T2D at a higher risk of developing cognitive decline or dementia.

RECOGNISED will apply innovative approaches to identify the molecular mechanisms involved in the high prevalence of cognitive impairment and dementia in T2D population and will use this knowledge to characterize clinical phenotypes (personalized medicine) based on retinal functional and structural characteristics and serum biomarkers in order to stratify the risk and severity of cognitive decline. Previously collected data from registries, cohorts and biobanks will be appropriately exploited and robust new data will be generated that will guide clinical recommendations and open up new therapeutic strategies. Ultimately, the RECOGNISED project will help to reduce the huge societal and economic burden associated with diabetes-related cognitive impairment. The main goals of the RECOGNISED project will be to:

  • Consolidate EATRIS capacities in the field of Personalised Medicine (particularly omics technologies) to better serve academia and industry and augment the number of EATRIS Innovation Hubs with large pharma;
  • Drive patient empowerment through active involvement in the infrastructure’s operations;
  • Expand strategic partnerships with research infrastructures and other relevant stakeholders; and
  • Further strengthen the long-term sustainability of the EATRIS financial model.

Recognised Consortium

The multidisciplinary RECOGNISED consortium consists of top research leaders in the field belonging to 15 prestigious institutions as well as EATRIS, IDF-Europe and Alzheimer Europe and 3 SMEs.

Work Packages

WP1 – General Coordination and Management
WP2 – Basic Research: Deciphering common molecular mechanisms leading to neurovascular pathology in Alzheimer’s brain and diabetic retina
WP3 – Prospective multicentric, crosssectional and cohort clinical study
WP4 – Central Reading and Imaging Processing
WP5 – Neuropsychological and quality of life evaluation
WP6 – Circulating Biomarkers
WP7 – Data Mining and System Biology
WP8 – Dissemination and Exploitation
WP9 – Communication Activities
WP10 – Ethics Requirements

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 847749. For more information please contact project manager Ben Lydall.

 

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