EATRIS-Plus – Flagship in Personalised Medicine

Project Acronym EATRIS-Plus
Funding Programme Horizon 2020
Budget 4,900,000 EUR
Coordinator EATRIS

EATRIS-Plus Project ran 1 January 2020 – 31 December 2023 (48 months). The project has now concluded and the information on this website is being updated to highlight the opportunities that our community can continue engaging in. While we are working on these updates, we encourage everyone to explore the Multi-Omics Toolbox (MOTBX), The Patient Engagement Resource Centre (PERC) and the Innovation Management Toolbox (IMT). Also don’t forget to take a look in the Publications and Deliverables section below for journal articles, pre-prints and other deliverables of the project.

In case of questions about specific opportunities contact the Project Manager via the contact form at the end of the page.

Ongoing Initiatives

Multi-omics Toolbox (MOTBX)

Multi-omics hub for translational research

Patient Engagement Resource Centre

For researchers to get started with patient engagement

EATRIS-Plus Staff Exchange Programme

Apply Now!

EATRIS Certificate of Commitment to Quality (ECCQ)

Accepting pilot applications

Ringtesting for Omics Platforms

Patient Engagement and Patient Advisory Committee (PAC)

Translational Toolkit for Global Researchers

Global Collaboration through Translation Together Initiative

Up to date free reference library of resources in rare disease translational medicine

News and Highlights

EATRIS-Plus in a nutshell

Our flagship project EATRIS-Plus aims to build further capabilities and deliver innovative scientific tools to support the long-term sustainability strategy of EATRIS as one of Europe’s key research infrastructures for Personalised Medicine.

The main goals of EATRIS-Plus are to:

  • Consolidate EATRIS capacities in the field of Personalised Medicine (particularly omics technologies) to better serve academia and industry and augment the number of EATRIS Innovation Hubs with large pharma;
  • Drive patient empowerment through active involvement in the infrastructure’s operations;
  • Expand strategic partnerships with research infrastructures and other relevant stakeholders, and
  • Further strengthen the long-term sustainability of the EATRIS financial model.

Efficient advancement of Personalised Medicine depends on the availability of validated patient-targeted biomarkers. However, as our capacity to identify genetic variants associated with complex diseases increases, these do not fully recapitulate the resulting disease phenotypes, and a more precise understanding of the molecular profiles are needed.

This realisation provides a rationale for the development of multi-omic approaches. In order to turn the multi-omic promises into a reality, systemic bottlenecks impacting the biomarker field needs to be overcome:

  • Poor levels of technological and analytical harmonisation;
  • Poor data stewardship and compliance to the FAIR (Findable, Accessible, Interoperable, and Reusable) principles;
  • Lack of understanding of the relationship between genomic biomarkers and downstream molecular markers (transcriptomic, proteomic, metabolomic, among others);
  • Lack of reliable control reference values for these biomarkers in healthy populations;
  • and Poor understanding of the clinical needs resulting in limited clinical adoption.

Tackling those issues in a systematic way is one of our main objectives. The consortium delivered a multi-omic toolbox to support cross omic analysis and data integration in clinical samples.


The omic tools were developed and tested with a real-setting demonstrator, a previously established cohort of 1,000 healthy individuals in Czechia upon whom genomic sequencing had been performed. During the project information available on this healthy individual cohort was supplemented with transcriptomic, proteomic and metabolomic data.

By providing such toolbox to the research community, EATRIS-Plus is the engine to enable high-quality research in the context of patient stratification and accelerating the implementation of Personalised Medicine solutions.

The Multi-Omics Toolbox can be accessed at


WP1 – Multi-omic technologies for Personalised Medicine

WP2 – Data Stewardship and integration of omic research in Personalised Medicine

WP3 – Quality Assessment for omic technologies

WP4 – Long-term Sustainability Planning

WP5 – Stakeholder Engagement

WP6 – Industry Collaboration and Open Innovation Models

WP7 – Training

WP8 – International Collaboration

WP9 – Coordination and Management

WP10 – Ethics Requirements

The consortium is composed of 20 partners including all current national nodes of the research infrastructure, academic representatives of new prospective member countries as well as umbrella organisations representing the patients’ voice and biotech companies.

Publications and Deliverables

Artificial Intelligence Enabling Improved Patient Treatment Strategies – Challenges and Recommendations

Preprint | Zenodo | December 2023

Quality criteria for global expansion of the repository of multi-omic reference values

Deliverable | Zenodo | December 2023

Multi-omics Quality Assessment in Personalized Medicine through EATRIS

Preprint BioRxiv | November 2023

The Multi-omics Toolbox (MOTBX): Empowering Multi-omics Research and Analysis for the Translational Medicine Community

Deliverable | Zenodo | November 2023

Ten quick tips for building FAIR workflows

PLOS Computational Biology | September 2023

Metabolomic predictors of phenotypic traits can replace and complement measured clinical variables in population-scale expression profiling studies

BMC Genomics | July 2022

Computational approaches for network-based integrative multi-omics analysis

Frontiers Molecular Biosciences | November 2022

FAIR Genomes metadata schema promoting Next Generation Sequencing data reuse in Dutch healthcare and research

Nature Scientific Data | April 2022

Tackling the translational challenges of multi-omics research in the realm of European personalised medicine: A workshop report.

Frontiers Molecular Bioscience | October 2022

EATRIS Certificate of Commitment to Quality - Eligibility Criteria


Evaluation of Methods for Improving Comparability of Cross-Omics Data from Different Cohorts


Sample Analysis Using Individual Omic Techniques and Data Outputs

Technological Reference Protocols for Transcriptomic, Proteomic and Metabolomic Analysis


EATRIS-Plus FAIRification Template and Workflows


Guidelines for the Establishment of Reference Values for Omics


Journal Article: A call to action for translational sciences in COVID-19 and future pandemics

Nature Reviews Drug Discovery | 28 January 2022

Biotech and SME Needs and Service Gaps in Relation to Research Infrastructures: Survey Report


Past Events

Sharepoint Login

Members of the EATRIS-Plus Project can enter the SharePoint platform here


Eliis Keidong
Member Engagement Officer