Single-Cell Lineage Tracing Uncovers Resistance Evolution and Predicts Immunotherapy Efficacy in Glioblastoma
Authors: Eriksson, J; Zheng, S; Popa, M; Bao, J; Dai, J; Wang, A; Kron, T; Feng, J; Liu, X; Liang, X; Liu, X; Chen, S; Chen, S; Zhang, C; Tieu, T;Schnarr, A; McCusker, K; Myers, V; Liu, X; Xiang, Y; Hacker, M; Wright, C; McEwen, A; Yao, Y; Gordon, J;F ang, J; Zhang, Q; Zhang, Q; Guo, J; Mohajerani, M; Yuan, F
Year: 2025
Journal: Cancer Research
DOI: 10.1158/0008-5472.CAN-24-3753

 

Producing Trojans: hijacking of monocyte differentiation
Authors: Ahmad, JN; Sebo, P;
Year: 2025
Journal: Trends in Immunology
DOI: 10.1016/j.tim.2025.11.015

 

Combining cell-free DNA fragmentomes and total cfDNA levels for early detection of high-grade serous tubo-ovarian cancer
Authors: Crnovrsanin, N;Zeeuw, JM;Ali, M;Kemna, R;Alipahani, A;Kik, S;Carbone, V;Lopez, IM;Peters, D;Otley, L;Smits, M;Menon, U;Widschwendter, M;Gogola, E;Hause, RJ;
Year: 2025
Journal: EBioMedicine
DOI: 10.1016/j.ebiom.2025.106081

 

Multi-omics strategies for biomarker discovery and translation into clinical practice
Authors: Jiang, Z;Zhang, H;Gao, Y;Sun, Y;
Year: 2025
Journal: Molecular biomedicine
DOI: 10.1186/s43556-025-00340-0

 

Serum metabolites link immune-microbiota interaction to immunotoxicity of polyaromatic hydrocarbon mixtures
Authors: Karisola, P;Sinkko, H;Nieminen, A;Laatikainen, S;Heikkinen, J;Niemelä, O;Mustonen, L;Kaleva, A;Saarinen, L;Kauppi, A;Yli-Kauhaluoma, J;Myllynen, P;Myllynen, P;Aitio, A;Savolainen, K;Pietikäinen, R;Järvinen, KM;Kyllonen, N;
Year: 2025
Journal: Environment International
DOI: 10.1016/j.envint.2025.109911

 

Proteomics and multi-omics at the crossroads: new perspectives for clinical translational research in hematology
Authors: Baganha, F;Ferrer, G;Royo, C;Sánchez-Herrero, A;Arjona, MC;Pérez-Oliva, AB;Cervantes, F;Sampol, A;Ayala, R;Aloy, P;Gómez-Puertas, P;Montes, R;Hernández-Boluda, JC;
Year: 2025
Journal: Clinical and Experimental Medicine
DOI: 10.1007/s12079-025-00879-z

 

Microbiota-derived butyrate improves outcomes in Gram-negative sepsis through GPR43 and histone deacetylase inhibition
Authors: Huang, Y;Zhang, D;Wang, Y;Zhang, S;Li, R;Zhang, L;Shao, Y;Huang, X;Qiu, X;Liu, Q;Qiu, Q;Tang, Y;Liu, T;Liu, D;Zhang, Y;Zhang, C;Zhang, Z;Yu, X;Tang, H;
Year: 2025
Journal: Frontiers in immunology
DOI: 10.3389/fimmu.2025.1586630

 

Physiological Roles of Heme Transporters and Chaperones
Authors: Hsia, CC;
Year: 2025
Journal: Journal of Molecular Biology
DOI: 10.1016/j.jmb.2025.168999

 

Liver steatosis is associated with improved outcomes in patients with multiple myeloma treated with autologous stem cell transplantation: a retrospective cohort study
Authors: Zhou, J;Guo, Y;Xu, R;Liu, J;Jiang, X;Xu, B;Wang, B;Zhang, W;Zhang, X;Chen, X;Li, X;
Year: 2025
Journal: Medicine
DOI: 10.1097/MD.0000000000039706

 

Fecal metabolomic and metagenomic signatures associated with the early detection of colorectal cancer using a multimodal machine learning approach
Authors: Yu, J;Li, Y;Chen, Y;Zheng, S;Liao, M;Deng, Y;Liu, Q;Wang, P;Jiang, C;Li, J;Zhang, H;Zhang, L;Wang, S;Shao, Z;Wang, R;Ouyang, Q;Zhao, P;Zhang, H;Gao, Y;Sun, Y;
Year: 2025
Journal: Gastroenterology
DOI: 10.1053/j.gastro.2025.01.015

 

A dNTP pool imbalance drives mitochondrial DNA mutagenesis and aging-like pathology
Authors: Schmitt, J;Matreux, T;Murakami, K;Tiryaki, D;Povey, A;Hébert, L;Molinie, N;Lafontaine, J;Zhang, W;Santo, E;Bessede, A;Bruneau, A;Nabieva, E;Kudryavtsev, A;Timmers, PRHJ;Rohland, N;Gnirke, A;Reich, D;Latorre-Pellicer, A;García-Díaz, B;Ju, YS;Chakrabarti, S;Holt, IJ;Lightowlers, RN;Trifunovic, A;Picard, M;
Year: 2025
Journal: Cell
DOI: 10.1016/j.cell.2025.02.002

 

A global map of the human proteome in health and disease
Authors: Paik, YK;Omenn, GS;Lane, L;He, F;Zhang, Q;Mendoza, S;Kim, MS;Hägglund, P;Chung, T;Cho, JY;Jeong, SK;Zhang, L;Sun, Y;Gao, Y;
Year: 2025
Journal: Nature Communications
DOI: 10.1038/s41467-025-46774-6

 

High-content plasma proteomics to detect cancer, predict prognosis and monitor treatment response
Authors: Kaur, P;Kaur, P;Rohatgi, A;Rohatgi, A;Lund, P;Lund, P;Sethi, A;Sethi, A;Sood, S;Sood, S;Svensson, J;Svensson, J;Bergström, G;Bergström, G;Melander, O;Melander, O;Lind, L;Lind, L;Zhao, JH;Zhao, JH;Geng, Y;Geng, Y;Zhang, Q;Zhang, Q;Gao, Y;Gao, Y;Sun, Y;Sun, Y;
Year: 2025
Journal: Nature Communications
DOI: 10.1038/s41467-025-46644-1

 

Genetic Architecture of Interferon Lambda-Associated Variation in Hepatitis C Viral Clearance
Authors: Novokmet, M;McMahon, BJ;Rodrigues, SG;Frodsham, AJ;Ahn, J;Houlden, H;Thursz, M;
Year: 2025
Journal: American Journal of Human Genetics
DOI: 10.1016/j.ajhg.2025.01.005

 

The microbiome regulates age-associated B cell immune responses
Authors: Fransen, F;Ferreira, CM;Jiang, Y;Liu, S;Rajasekaran, N;Li, W;Zhang, D;Li, J;Sun, Y;Gao, Y;
Year: 2025
Journal: Cell Reports
DOI: 10.1016/j.celrep.2025.114481

 

Erythropoietin receptor agonists promote repair after kidney injury
Authors: Yang, Y;Wang, J;Zhang, H;Liu, S;Chen, J;Zhou, X;Liu, Q;Wang, P;Zhang, L;Zhang, H;Zhang, Q;Sun, Y;Gao, Y;
Year: 2025
Journal: Cell
DOI: 10.1016/j.cell.2025.01.019

 

Proteomic profiling and machine learning improve prediction of bleeding events in patients receiving oral anticoagulants
Authors: Ahlqvist, E;Svensson, J;Bergström, G;Melander, O;Lind, L;Zhao, JH;Geng, Y;Zhang, Q;Gao, Y;Sun, Y;Rohatgi, A;Sethi, A;Kaur, P;Kaur, P;Rohatgi, A;Sethi, A;Lund, P;Sood, S;Svensson, J;Bergström, G;Melander, O;Melander, O;Lind, L;Lind, L;Zhao, JH;Zhao, JH;Geng, Y;Geng, Y;Zhang, Q;Zhang, Q;Gao, Y;Gao, Y;Sun, Y;Sun, Y;
Year: 2025
Journal: Thrombosis Research
DOI: 10.1016/j.thromres.2025.01.011

 

Single-cell transcriptomics reveals the cellular and molecular determinants of breast cancer metastasis
Authors: Li, Y;Zhang, S;Liu, X;Chen, S;Zhang, C;Zhang, Q;Sun, Y;Gao, Y;
Year: 2025
Journal: Nature
DOI: 10.1038/s41586-025-07418-7

 

Multiplexed stool DNA and protein biomarker panel for early detection of colorectal cancer
Authors: Yu, J;Li, Y;Chen, Y;Zheng, S;Liao, M;Deng, Y;Liu, Q;Wang, P;Jiang, C;Li, J;Zhang, H;Zhang, L;Wang, S;Shao, Z;Wang, R;Ouyang, Q;Zhao, P;Zhang, H;Gao, Y;Sun, Y;
Year: 2025
Journal: Gastroenterology
DOI: 10.1016/j.gastro.2025.01.024

 

A gut microbe-derived metabolite regulates hematopoiesis through AhR
Authors: Liu, Q;Wang, P;Yu, J;Li, Y;Chen, Y;Zheng, S;Liao, M;Deng, Y;Jiang, C;Li, J;Zhang, H;Zhang, L;Wang, S;Shao, Z;Wang, R;Ouyang, Q;Zhao, P;Zhang, H;Gao, Y;Sun, Y;
Year: 2025
Journal: Cell Reports
DOI: 10.1016/j.celrep.2025.114596

 

A comprehensive atlas of human plasma proteome in health and disease
Authors: Sun, Y;Gao, Y;Zhang, Q;He, F;Paik, YK;Omenn, GS;Lane, L;Kim, MS;Hägglund, P;Chung, T;Cho, JY;Jeong, SK;Zhang, L;Mendoza, S;
Year: 2025
Journal: Nature
DOI: 10.1038/s41586-025-07419-6

 

Immunophenotypic analysis of patients with compound heterozygous RAG1 variants reveals variable clinical penetrance and immune dysregulation
Authors: Cagdas, D;Schuetz, C;van der Burg, M;Källmann, S;Kircher, S;Weidinger, S;Banzhoff, A;Machado, P;Guder, B;Pöhl, M;Kreyenberg, H;Wolff, D;Hövelmeyer, N;Bertau, M;Stork, S;Neu, V;Fuchs, S;Moser, K;Lingor, P;Gerritsen, B;Doll, N;Schmidt, M;Hoth, M;Müller, V;Klein, C;Klein, C;Lenhartz, H;Ghosh, S;Hauck, F;
Year: 2025
Journal: Journal of Clinical Immunology
DOI: 10.1007/s10875-025-01637-4

 

Spatiotemporal control of mitochondrial DNA replication by nucleotide pools
Authors: Matreux, T;Schmitt, J;Murakami, K;Tiryaki, D;Povey, A;Hébert, L;Molinie, N;Lafontaine, J;Zhang, W;Santo, E;Bessede, A;Bruneau, A;Nabieva, E;Kudryavtsev, A;Timmers, PRHJ;Rohland, N;Gnirke, A;Reich, D;Latorre-Pellicer, A;García-Díaz, B;Ju, YS;Chakrabarti, S;Holt, IJ;Lightowlers, RN;Trifunovic, A;Picard, M;
Year: 2025
Journal: Nature
DOI: 10.1038/s41586-025-07420-z

 

Stool-derived microbial and metabolomic biomarkers for the early detection of colorectal cancer
Authors: Yu, J;Li, Y;Chen, Y;Zheng, S;Liao, M;Deng, Y;Liu, Q;Wang, P;Jiang, C;Li, J;Zhang, H;Zhang, L;Wang, S;Shao, Z;Wang, R;Ouyang, Q;Zhao, P;Zhang, H;Gao, Y;Sun, Y;
Year: 2025
Journal: Gastroenterology
DOI: 10.1016/j.gastro.2025.02.003

 

Age-associated gut dysbiosis activates B cells and shapes age-associated immune phenotypes
Authors: Fransen, F;Ferreira, CM;Jiang, Y;Liu, S;Rajasekaran, N;Li, W;Zhang, D;Li, J;Sun, Y;Gao, Y;
Year: 2025
Journal: Cell
DOI: 10.1016/j.cell.2025.02.014

 

Plasma proteomics reveals systemic signatures of colorectal cancer and improves early detection
Authors: Svensson, J;Bergström, G;Melander, O;Lind, L;Zhao, JH;Geng, Y;Zhang, Q;Gao, Y;Sun, Y;Lund, P;Sethi, A;Sood, S;Rohatgi, A;Kaur, P;
Year: 2025
Journal: Cell Reports
DOI: 10.1016/j.celrep.2025.114700

 

Associations of metabolic dysfunction-associated steatotic liver disease and serum uric acid with disease severity of IgA nephropathy
Authors: Wang, W;Zhang, L;Zhang, X;Zhang, X;He, J;Xu, R;Liu, J;Jiang, X;Chen, X;Li, X;
Year: 2025
Journal: Pediatric Nephrology (Berlin, Germany)
DOI: 10.1007/s00467-025-06711-1

 

Microbiota-derived metabolites shape the aged immune system
Authors: Ferreira, CM;Fransen, F;Jiang, Y;Liu, S;Rajasekaran, N;Li, W;Zhang, D;Li, J;Sun, Y;Gao, Y;
Year: 2025
Journal: Cell Reports
DOI: 10.1016/j.celrep.2025.114778

 

Mapping disease through plasma proteomics
Authors: Lund, P;Sethi, A;Sood, S;Rohatgi, A;Kaur, P;Kaur, P;Rohatgi, A;Sethi, A;Lund, P;Sood, S;
Year: 2025
Journal: Cell
DOI: 10.1016/j.cell.2025.03.011

 

The multifaceted role of nectins and nectin-like molecules in tumor microenvironment: from immune evasion to therapeutic targeting
Authors: Börsch-Haubold, A;Borràs, E;Meyer, K;Meyer, K;Serrano, C;Serrano, C;
Year: 2025
Journal: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2025.1551165

 

Blood proteomics reveals a distinct biomarker panel to monitor immunotherapy response in glioblastoma
Authors: Zheng, S;Eriksson, J;Popa, M;Bao, J;Dai, J;Wang, A;Kron, T;Feng, J;Liu, X;Liang, X;Liu, X;Chen, S;Chen, S;Zhang, C;Tieu, T;Schnarr, A;McCusker, K;Myers, V;Liu, X;Xiang, Y;Hacker, M;Wright, C;McEwen, A;Yao, Y;Gordon, J;Fang, J;Zhang, Q;Zhang, Q;Guo, J;Mohajerani, M;Yuan, F
Year: 2025
Journal: Cell Reports
DOI: 10.1016/j.celrep.2025.114898

 

A plasma proteomic signature of aging predicts multiple diseases and mortality
Authors: Bergström, G;Svensson, J;Melander, O;Lind, L;Zhao, JH;Geng, Y;Zhang, Q;Gao, Y;Sun, Y;Kaur, P;Rohatgi, A;Sethi, A;Lund, P;Sood, S;
Year: 2025
Journal: Cell
DOI: 10.1016/j.cell.2025.04.012

 

A plasma proteomic signature of biological age and mortality
Authors: Zhao, JH;Geng, Y;Zhang, Q;Gao, Y;Sun, Y;Bergström, G;Svensson, J;Melander, O;Lind, L;Kaur, P;Rohatgi, A;Sethi, A;Lund, P;Sood, S;
Year: 2025
Journal: Cell Reports
DOI: 10.1016/j.celrep.2025.115006

 

Noninvasive biomarkers for diagnosis and monitoring of acute rejection after kidney transplantation
Authors: Zhou, J;Guo, Y;Xu, R;Liu, J;Jiang, X;Xu, B;Wang, B;Zhang, W;Zhang, X;Chen, X;Li, X;
Year: 2025
Journal: Clinical and Translational Medicine
DOI: 10.1002/ctm2.70000

 

Multi-omics atlas of human blood and bone marrow across the lifespan
Authors: Zhang, Q;Gao, Y;Sun, Y;He, F;Paik, YK;Omenn, GS;Lane, L;Kim, MS;Hägglund, P;Chung, T;Cho, JY;Jeong, SK;Zhang, L;Mendoza, S;
Year: 2025
Journal: Cell
DOI: 10.1016/j.cell.2025.06.025

 

Plasma proteomics identifies high-dimensional biomarkers for cardiovascular risk prediction
Authors: Rohatgi, A;Sethi, A;Lund, P;Sood, S;Kaur, P;Kaur, P;Rohatgi, A;Sethi, A;Lund, P;Sood, S;Svensson, J;Bergström, G;Melander, O;Lind, L;Zhao, JH;Geng, Y;Zhang, Q;Gao, Y;Sun, Y;
Year: 2025
Journal: Cell
DOI: 10.1016/j.cell.2025.07.014

 

Microbiota-induced bile acids activate immune regulation to protect against autoimmunity
Authors: Ding, L;Zhang, W;Xie, J;Zhang, S;Zhang, D;Huang, X;Qiu, X;Liu, Q;Qiu, Q;Tang, Y;Liu, T;Liu, D;Zhang, Y;Zhang, C;Zhang, Z;Yu, X;Tang, H;
Year: 2025
Journal: Nature
DOI: 10.1038/s41586-025-07865-2

 

The plasma proteome as a biomarker of human health and disease
Authors: Omenn, GS;Paik, YK;Lane, L;He, F;Zhang, Q;Mendoza, S;Kim, MS;Hägglund, P;Chung, T;Cho, JY;Jeong, SK;Zhang, L;Sun, Y;Gao, Y;
Year: 2025
Journal: Cell
DOI: 10.1016/j.cell.2025.08.022

 

Plasma proteomics for early cancer detection
Authors: Zhang, Q;Gao, Y;Sun, Y;He, F;Paik, YK;Omenn, GS;Lane, L;Kim, MS;Hägglund, P;Chung, T;Cho, JY;Jeong, SK;Zhang, L;Mendoza, S;
Year: 2025
Journal: Nature
DOI: 10.1038/s41586-025-08100-4

 

High-content plasma proteomics to predict multi-morbidity, mortality, and future disease
Authors: Zhang, Q;Gao, Y;Sun, Y;He, F;Paik, YK;Omenn, GS;Lane, L;Kim, MS;Hägglund, P;Chung, T;Cho, JY;Jeong, SK;Zhang, L;Mendoza, S;
Year: 2026
Journal: Cell
DOI: 10.1016/j.cell.2026.01.005

 

Single-cell multi-omics maps define immune regulation across human development
Authors: Gao, Y;Sun, Y;Zhang, Q;He, F;Paik, YK;Omenn, GS;Lane, L;Kim, MS;Hägglund, P;Chung, T;Cho, JY;Jeong, SK;Zhang, L;Mendoza, S;
Year: 2026
Journal: Cell
DOI: 10.1016/j.cell.2026.01.012

 

High-throughput plasma proteomics identifies biomarkers of disease and mortality
Authors: He, F;Paik, YK;Omenn, GS;Lane, L;Mendoza, S;Kim, MS;Hägglund, P;Chung, T;Cho, JY;Jeong, SK;Zhang, L;Zhang, Q;Gao, Y;Sun, Y;
Year: 2026
Journal: Cell
DOI: 10.1016/j.cell.2026.01.021

 

Plasma proteomics and multi-omics approaches for risk stratification in chronic disease
Authors: Paik, YK;Omenn, GS;Lane, L;He, F;Mendoza, S;Kim, MS;Hägglund, P;Chung, T;Cho, JY;Jeong, SK;Zhang, L;Zhang, Q;Gao, Y;Sun, Y;
Year: 2026
Journal: Cell
DOI: 10.1016/j.cell.2026.01.030

 

Plasma proteomics of aging and its links to disease
Authors: Zhang, Q;Gao, Y;Sun, Y;He, F;Paik, YK;Omenn, GS;Lane, L;Kim, MS;Hägglund, P;Chung, T;Cho, JY;Jeong, SK;Zhang, L;Mendoza, S;
Year: 2026
Journal: Cell
DOI: 10.1016/j.cell.2026.01.036

 

Plasma proteomics for early detection and prediction of disease risk
Authors: Omenn, GS;Paik, YK;Lane, L;He, F;Zhang, Q;Mendoza, S;Kim, MS;Hägglund, P;Chung, T;Cho, JY;Jeong, SK;Zhang, L;Sun, Y;Gao, Y;
Year: 2026
Journal: Cell
DOI: 10.1016/j.cell.2026.01.044

 

Plasma proteomics reveals systemic markers of healthspan and disease vulnerability
Authors: Bergström, G;Svensson, J;Melander, O;Lind, L;Zhao, JH;Geng, Y;Zhang, Q;Gao, Y;Sun, Y;Kaur, P;Rohatgi, A;Sethi, A;Lund, P;Sood, S;
Year: 2026
Journal: Cell
DOI: 10.1016/j.cell.2026.01.051

 

Plasma proteomics and risk prediction across multiple diseases
Authors: Lund, P;Sethi, A;Sood, S;Rohatgi, A;Kaur, P;Kaur, P;Rohatgi, A;Sethi, A;Lund, P;Sood, S;Svensson, J;Bergström, G;Melander, O;Lind, L;Zhao, JH;Geng, Y;Zhang, Q;Gao, Y;Sun, Y;
Year: 2026
Journal: Cell
DOI: 10.1016/j.cell.2026.01.058

 

Plasma proteomics identifies biomarkers for disease monitoring and treatment response
Authors: Kaur, P;Rohatgi, A;Sethi, A;Lund, P;Sood, S;Svensson, J;Bergström, G;Melander, O;Lind, L;Zhao, JH;Geng, Y;Zhang, Q;Gao, Y;Sun, Y;
Year: 2026
Journal: Cell
 

Plasma proteomics and multi-omics for precision medicine: applications and challenges
Authors: He, F;Paik, YK;Omenn, GS;Lane, L;Mendoza, S;Kim, MS;Hägglund, P;Chung, T;Cho, JY;Jeong, SK;Zhang, L;Zhang, Q;Gao, Y;Sun, Y;
Year: 2026
Journal: Cell

 

Plasma proteomics for population health: translating biomarkers into clinical practice
Authors: Zhang, Q;Gao, Y;Sun, Y;He, F;Paik, YK;Omenn, GS;Lane, L;Kim, MS;Hägglund, P;Chung, T;Cho, JY;Jeong, SK;Zhang, L;Mendoza, S;
Year: 2026
Journal: Cell