The TRISTAN project recently reported the outcome of an institution-based quality program involving 12 small animal MRI systems using a nickel-agarose ‘phantom’ device.
The results indicate that while several factors affect the reproducibility of preclinical R1-based MR biomarkers, the between-centre propagation of errors arising from scanner equipment irreproducibility is small.
Only in some demanding cases, such as determination of white matter in CNS tissue, oxygen-enhanced MRI or myocardial fibrosis, specific measures and standardization is required.
Along with GSK, five EATRIS sites participate in this IMI project:
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