With the help of NeurATRIS, French node of EATRIS, the French Club of Glial Cells and the GDR Microglia and neuroinflammation offered two mini-symposia on November 25 and December 3, 2020. The recordings are now available for viewing on EATRIS Youtube channel.
INNOVATING THERAPIES FOR GLIAL CELLS RELATED DISEASES
The diseases of the nervous system including tumors are among the most dreadful diseases in humans. While the final outcome of these diseases is almost invariably due to neuronal dysfunction and death, glial cells often appear to be at the origin or to largely participate to the neuron unsettling. Thus, designing therapies directly targeting glial cells is highly relevant for the large majority of diseases of the central and peripheral nervous system (CNS/PNS).
As glial cells provide an undeniable and significant support to neuron function and survival, an exciting novel way to tackle nervous system diseases is to design therapies that will modify, improve or sustain this support in order to prevent neuronal cell dysfunction or death.
In this webinar, 3 reknowned speakers illustrate this strategy using various technological approaches and treatments in diverse types of glial-cells related pathologies of the CNS and PNS: Caroline Sevin, Piotr Topilko and Nicolas Tricaud.
THE ROLE OF MICROGLIA IN HEALTH AND DISEASE
As microglia were found to play major role in CNS development and interacts with neurons in the healthy brain, an exciting novel way to tackle nervous system diseases is to better understand how microglia during neuroinflammation contribute to neuronal cell dysfunction or death. In this symposium, we propose to apprehend the role of microglial cells in early stage of CNS diseases through various CNS pathological models. The goal is to offer a large enough diversity of speakers to be attractive for a large amount of neuroscientists interested in the fields of microglia, neuroinflammation and neurodegeneration.
- Rosa Paolicelli (Université de Lausanne, Switzerland): “The many roles of microglia in neurodegeneration”
- Juliette van Steenwinckel (Université Paris Diderot, France) “Microglial perturbation in neurodevelopmental disorders induced by early exposure to inflammation”
- Pierre Szepetowski / Sylvian Bauer (INMED, France) “Early cellular and molecular alterations in cytomegalovirus infection of the fetal brain: microglia and chemokines as therapeutic targets?”