University Medical Center Utrecht (UMCU)

Contact

Head of the facility	Prof. dr. W. van Solinge

Expertise

Technologies	Luminex MesoScale Discovery(MSD) LC-MS Protein chips OLINK
Purposes	Research Clinical use
Applications	Biomarkers discovery and development Diagnostics and personalised disease profiling Disease processes research

Features

Collaboration with industry where the institute collaborated with Proteomics expertise (in the last 5 years)	>10
Certifications	ISO15189 ISO 9001

Track record

Key opinion leaders

Stefan Nierkens: translation of exploratory proteomice analyses to clinical implementation Eveline Delemarre: data analyses

Publications

Bakker DS, Nierkens S, Knol EF, et al. Confirmation of multiple endotypes in atopic dermatitis based on serum biomarkers [published online ahead of print, 2020 Jun 8]. J Allergy Clin Immunol. 2020;S0091-6749(20)30801-0. doi:10.1016/j.jaci.2020.04.062 Ariëns LFM, van der Schaft J, Bakker DS, et al. Dupilumab is very effective in a large cohort of difficult-to-treat adult atopic dermatitis patients: First clinical and biomarker results from the BioDay registry. Allergy. 2020;75(1):116-126. doi:10.1111/all.14080 Thijs JL, Fiechter R, Giovannone B, et al. Biomarkers detected in dried blood spots from atopic dermatitis patients strongly correlate with disease severity. Allergy. 2019;74(11):2240-2243. doi:10.1111/all.13839 Wienke J, Bellutti Enders F, Lim J, et al. Galectin-9 and CXCL10 as Biomarkers for Disease Activity in Juvenile Dermatomyositis: A Longitudinal Cohort Study and Multicohort Validation. Arthritis Rheumatol. 2019;71(8):1377-1390. doi:10.1002/art.40881 Kuiper JJ, Beretta L, Nierkens S, et al. An Ocular Protein Triad Can Classify Four Complex Retinal Diseases. Sci Rep. 2017;7:41595. Published 2017 Jan 27. doi:10.1038/srep41595

DATA ANALYSIS for

• Proteomics
• Metabolomics
• Omics data integration / systems biology

DATA INTERPRETATION for

• Proteomics
• Metabolomics
• Omics data integration / systems biology

DATA MANAGEMENT for

• FAIR data

STATISTICS

• SPSS; nonmem
• Molecular profiling (omics and others)
• Expertise in clinical design of experiments, clinical statistics
• Metadata (patient/sample information)
• Methods and policies for information infrastructure, including privacy and security

BIOINFORMATICS

• Data integration (“Systems biology”)
• Development of new algorithms, e.g. new decision algorithms, new sequence aligners for NGS data, etc.
• Informatics methods to support clinical decisions (diagnostic, predictive tests)

OMICS INTEGRATION METHODS

• Published tools
• Own scripts/software

Contact

Facility	ARCADIA
Head of the facility	Imo Hoefer, MD, PhD, FESC

Expertise

Technologies	NGS-Whole genome sequencing (WGS) NGS-Exome sequencing(WES) Genotyping qPCR
Purposes	Research Clinical use
Applications	Diagnostics and personalised disease profiling Epidemiology

Features

Collaboration with industry where the institute collaborated with Genomics expertise (in the last 5 years)	<10
Certifications	ISO 9001

Expertise

Technologies	RT-PCR Microarrays NGS- RNA sequencing
Purposes	Research
Applications	Biomarkers discovery and development Single cells studies

Features

Certifications	ISO 9001