|Address||Stem Cell Engineering Research Group
Instituto Superior Técnico - Campus TagusPark
Av. Prof. Doutor Aníbal Cavaco Silva
2744-016 Porto Salvo, Portugal
|Platforms||ATMP & Biological|
The Stem Cell Engineering Research Group (SCERG) of the Institute for Bioengineering and Biosciences (iBB) aims at the development of cell production systems for the ex-vivo expansion of stem cells and/or their controlled differentiation into specific cell types to generate the large numbers of high quality stem/progenitor cell subsets needed for Regenerative Medicine settings, as well as for the development of in vitro models for disease modelling and drug testing. SCERG activities are focused on the safe, robust and reproducible manufacturing of human stem cells and their derivatives by employing process engineering, including bioreactor design, bioseparations, microscale technology and systems biology, being able to understand how process variables influence the critical quality attributes of the cells produced.
Human hematopoietic stem/progenitor cells and mesenchymal stromal cells, as well as human pluripotent stem cells (both embryonic stem cells and induced pluripotent stem cells) and their neural and cardiac derivatives, have been used as model systems.
SCERG relies on a cross-disciplinary strategy combining Bioprocess Engineering with Stem Cell Biology focusing on six major Research Themes:
– Clinical Manufacturing of Stem Cell-based Therapies
– Bioprocessing of Human Pluripotent Stem Cells for Regenerative and Precision Medicine
– Bioreactor and Microcarrier Technologies for Stem Cell expansion and differentiation
– Gene Delivery Strategies to Modulate Stem Cell Function
– Stem Cell Biosystems Engineering
– Designing Biomaterials and Devices for Stem Cell Engineering
iBB is a research unit in bioengineering, biological sciences, biospectroscopy and interfaces, at Instituto Superior Técnico (IST), Universidade de Lisboa aiming to promote excellent cross-disciplinary research, development, post-graduate education, knowledge transfer and dissemination within the biology, chemistry and engineering disciplines with impact on Human Health and Bioeconomy.