KTH Royal Institute of Technology

Address Brinellvägen 8, Stockholm
Platforms Biomarkers

Since its founding in 1827, KTH Royal Institute of Technology in Stockholm has grown to become one of Europe’s leading technical and engineering universities, as well as a key centre of intellectual talent and innovation. KTH is Sweden’s largest technical research and learning institution and home to students, researchers and faculty from around the world dedicated to advancing knowledge.

KTH’s focus is on research and education for a brighter, more sustainable tomorrow and KTH works closely with the industry and society in the pursuit of sustainable solutions to some of humanity’s greatest challenges: climate change, future energy supply, urbanisation and digitalisation.

Basic and applied research are performed side-by-side and interdisciplinary research is conducted in parallel with work in specific fields. This approach encourages versatile solutions and the innovative climate creates many opportunities to realise great ideas.

The educational programmes foster a new generation of engineers, architects, teachers and undergraduate engineers.


 

Plasma Profiling facility at Science for Life Laboratory (SciLifeLab)

Science for Life Laboratory (SciLifeLab) is a national center for advanced life science in Sweden. Located at SciLifeLab in Stockholm, the Plasma Profiling facility is one of SciLifeLab’s National Facilities. The Plasma Profiling facility has the potential to supports clinical biomarkers research providing infrastructure and expertise to apply cutting edge immunoassays technologies. Our focus is on the development and application of robust immunoassays for protein quantification in biofluids in pre-clinical and translational research.

 

Our infrastructure already includes :

(i) Systems for Olink’s PEA platfrom (Biomark HD, Fluidigm®) for high-multiplexed antibody based proteomic profiling suitable for discovery study;

(ii) Luminex instrument for applicaton of commercial  and/or in house developed bead-based quantitative immunoassay (2x FLEXMAP 3D, 1x MAGPIX), the Luminex low-plex format is optimal for verification and validation biomarker studies ;

(iii)automated microfluidic immunoassays (ELLA,ProteinSimple®) which features robustness and automation to get highly reproducible data to move biomarker studies one step forward into clinical diagnostics. Our instrumentation also includes robots for liquid handling (1x FLUENT, Tecan; 2x EVO150, Tecan) and precision transfer (1x SELMA, CyBio®), as well as automated systems for processing magnetic beads (KingFisher Flex, Thermo; EL406 Washer Dispenser, Biotek).

The Facility has also access to the unique collection of ~50,000 antibodies and to full recombinant proteins from the Human Protein Atlas project. this give us the possibility to screen and select optimal reagent to develop robust immunoassays in biofluids.

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