IRCCS Istituto Romagnolo per lo Studio dei Tumori “Dino Amadori” – IRST Srl

Address Via Piero Maroncelli, 40
47014 Meldola (FC),
Italy
Platforms ATMP & Biological, Biomarkers, Small Molecules

IDENTITY AND BACKGROUND

Since its inauguration in 2007, IRST Cancer Institute has broken new grounds in multiple areas of cancer research, with outstanding clinical programs, innovative preclinical research and high-level training and educational initiatives. IRST provides state-of-the-art diagnosis and treatment in a wide range of cancer  fields, resulting in top quality healthcare.

The Institute offers individual Precision Medicine Programs tailored to the biofunctional and molecular characteristics of patients’ tumors, contributing to the development of clinical and research tools and practices that benefit patients and foster collaborative partnerships with other national and international healthcare and research organizations of excellence.

Situated in Romagna, a region in the northeast of Italy, IRST covers an area of over 1.1 million inhabitants and is fully integrated within the National Health Service. Specifically, it is a public-private partnership with:

  • Emilia-Romagna Region;
  • AUSL Romagna;
  • University of Bologna;
  • Istituto Oncologico Romagnolo (IOR), a cancer charity dedicated to raising funds for patients and research at IRST, also provides support in other areas including health education campaigns, a volunteer service, and the establishment of a Cancer Registry and Palliative Care Network;
  • Banking foundations.

The Institute is a multispecialty center with a number of high-complexity clinical specialties (e.g. radiometabolic therapy, high-precision radiotherapy, cellular therapies, immunotherapy) for which there is a dedicated inpatient unit and an outpatient clinic.

IRST is Coordinating Center of the Wide Area of Romagna Oncology Network and, as such, organizes and drives:

  • Cancer research and clinical trials;
  • The research infrastructure (highly skilled study coordinators, data managers, biostatisticians and project managers) needed to promote, carry out and evaluate research and cancer care (IRST also serves as Contract Research Organization for external studies);
  • Treatments with emerging or innovative technologies;
  • Continuous training in the field of oncology.

RESEARCH

IRST is a young and emerging Institute whose energy and passion spills over onto the many dedicated and dynamic physicians, scientists and research managers operating in a highly-tuned environment where the onus is on finding, observing, hypothesizing, studying and resolving the many issues inherent to the complex, constantly evolving and multifaceted nature of cancer.

Within this context, IRST plays a leading role alongside other institutes of excellence forming part of the Italian Ministry of Health Network (among which Alliance Against Cancer [ACC], the largest Italian organization for cancer research, established in 2002 by the Italian Ministry of Health as a network of high-standard institutes for comprehensive cancer patient care and research (IRCCS)). The Institute is also extremely active in the international scenario, as highlighted by the numerous scientific collaborations with other clinical and research centers.

Research, alongside healthcare, is one of the fundamental pillars of IRST and focuses on the following main areas: basic science, translational research, clinical research and personalized risk assessment.

These areas are key to designing specific lines of research and development around which projects and studies are based focusing on:

  1. Appropriateness, outcomes, drug value and organizational models for the continuity of diagnostic-therapeutic pathways in oncology.
  2. Innovative therapies, phase I-III clinical trials and therapeutic strategy trials based on preclinical models, oncoimmunological mechanisms and nanovectors.
  3. Precision, gender and ethnicity-based medicine and geroscience: genetic-molecular mechanisms in the development, characterization and treatment of tumors.
  4. Genetics and environment in the development and progression of tumors and inhibitory mechanisms. Exposomics and primary and secondary prevention.

More recent fields of research development are:

  • CART T-cell therapy: a new era in cancer immunotherapy
  • Nuclear medicine in the context of personalized medicine
  • Breast cancer: new personalized screening approaches
  • Health economics and outcome research (HEOR)
  • Clinical omics – molecular diagnostics in personalized medicine
  • Single cell multi-omics analysis: R&D
  • Drug Discovery and Phase I clinical trials

RESEARCH INFRASTRUCTURES

IRST has specific inter-related infrastructures to optimize research activities:

  • Unit of Biostatistics and Clinical Trials, which plays an active role in the planning and implementation of clinical protocols, data quality control and standardization, and statistical data analysis. The Unit’s activities include all those of a Contract Research Organization (CRO).
  • The Research and Innovation (R&I) Unit provides specialist advice aimed at maximizing IRST’s research success and income, identifying projects, partnership and intellectual property opportunities and successfully exploiting innovative ideas. For over 10 years, the R&I Unit at IRST, working closely with the Ministry of Health, Ministry of Economic Development and University and Research (MIUR), has provided vital information, support and assistance for researchers taking part in national and European programs, collaborative partnerships and initiatives (today, with particular reference to Horizon Europe).
  • The tech-transfer Unit (TT) is the first point of contact for business, facilitating access to IRST’s expertise for consultancy and research development, representing a point of reference for public and private R&D, SMEs and start-ups.
  • Big Data Unit, implements software and platforms to monitor clinical and research activities and to evaluate the benefits and challenges of innovations and interventions.
  • The Bioinformatics Unit supports research groups with computational and biostatistical services. Playing more than simply a supporting role, the unit proactively identifies and develops novel bioinformatics projects to complement and, in several instances drive, biologic research at IRST. The unit develops innovative data analysis tools, visualization software and database resources for genomics research.

IRST is an active member of specific European Research Infrastructures.

BIOSCIENCES LABORATORY

The activities of the Biosciences Laboratory can be divided into two main synergic areas:

  • basic and preclinical experimental research;
  • biomolecular diagnostics.

The two areas are mutually interdependent but maintain their organizational autonomy. Research projects are conceived and developed in close collaboration with the Clinical Units of the Institute. In addition to the “basic” equipment normally present in any research laboratory, the Biosciences Laboratory at IRST boasts a number of state-of-the-art instruments. The current orientation of pharmacological research is based on the use of drugs that act on specific biomolecular targets, and on their combination with conventional cytotoxic agents. It is therefore essential to have diagnostic-analytical instruments capable of correctly determining the presence and functionality of such biomolecular targets within the tumor cell.

The laboratory is also involved in the development of the Institute’s Biobank which is part of the national Biobank Web Project (BBMRU) and, consequently, of the European organization of Cancer Biobanks (BBMRI-ERIC).

To facilitate this type of organization, the laboratory is made up of a large common area, shared by all operators, and different environments with highly specialized equipment and dedicated personnel. These environments can be accessed by other laboratory operators when they need to use specific equipment for their research projects.

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Emanuela Oldoni

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