IRCCS Istituto Giannina Gaslini (IGG)

Address Via Gerolamo Gaslini 5,
16147 Genova
Italia
Platforms ATMP & Biological, Biomarkers, Imaging & Tracing, Small Molecules

The Giannina Gaslini Istitute is a National Public Children’s Hospital and Research Institute located in Genoa, Italy. It was founded in 1938 by an act of love and solidarity of Senator Gerolamo Gaslini. In 1956 the Istitute Gaslini was recognized as national public children’s hospital and research institute. Its activities include health care, research, teaching, and constant education of the hospital staff. Research is a strategic objective of the Istitute and is mainly aimed to translating research results into the clinical practice. The Istitute Gaslini is a multidisciplinary, highly specialized reference centre with national and international catchment area. It is the only hospital in Italy providing specialist and sub-specialist care, both medical and surgical, for mothers and children. Therefore, it is a national referral centre for complex diseases affecting newborns, children, and adolescents requiring highly specialised treatment.

In 2007/2008 the Gaslini Istitute obtained the desired accreditation recognition of the Joint Commission International whose standards aim to the continuous improvement of assistance always supported by qualified and excellent research.

In 2019, the agreement between the Giannina Gaslini Istitute and the Italian Istitute of Technology (IIT) found its operational conclusion, in particular referring to the Joint Lab of Genomics aspects, which presents aspects of both high quality research and of highly specialized complex diagnostics.

Expertise

Technologies
  • RT-PCR
  • Microarrays
Purposes
  • Research
Applications
  • Biomarkers discovery and development
  • Diagnostics and personalised disease profiling
  • Non coding RNA analysis (miRNA, lncRNA, sRNA..)

Expertise

Technologies
  • Western Blot
  • Isoelectric focusing (IEF)
  • Capillary electrophoresis(EC)
  • LC-MS
  • Liquid chromatography (HPLC, UHPLC)
Purposes
  • Research
Applications
  • Biomarkers discovery and development
  • Diagnostics and personalised disease profiling
  • Disease processes research
  • Expression proteomics
  • Interaction proteomics and protein networks

Features

% of TIME involved in technology/methods development/innovation/intellectual property related to Proteomics 30%

Track record

Key opinion leaders
  • M. Mann
  • R. Aebersold
  • N. Slavov
  • J. Olsen
  • M. MacCoss
  • S. Gygi
  • A. Heck
Publications

Expertise

Technologies
  • High performance liquid chromatography (HPLC,UHPLC)
  • LC-MS
  • Untargeted metabolomics assays
  • Targeted metabolomic assays
Purposes
  • Clinical use
Applications
  • Biomarkers discovery and development
  • Diagnostics and personalised disease profiling
  • Disease processes research
  • Therapeutic development

Features

Collaboration with industry where the institute collaborated with Metabolomics expertise (in the last 5 years) <10
% of TIME involved in technology/methods development/innovation/intellectual property related to Metabolomics 40%

Track record

Key opinion leaders
  • Fiehn Oliver
  • H. Tsugawa

DATA ANALYSIS for

  • Proteomics
  • Metabolomics

DATA INTERPRETATION for

  • Proteomics
  • Metabolomics

STATISTICS

  • Molecular profiling (omics and others)
  • Expertise in clinical design of experiments, clinical statistics
  • Metadata (patient/sample information)

BIOINFORMATICS

  • Proteins and Metabolites annotation
  • Expression profiling with omics for proteins and metabolites
  • Data integration (“Systems biology”)
  • Development of new algorithms, e.g. new decision algorithms, new sequence aligners for NGS data, etc.
  • Informatics methods to support clinical decisions (diagnostic, predictive tests)
  • Imaging

OMICS INTEGRATION METHODS

  • Published tools (MaxQuant, MSFragger, MetaMorpheus, Perseus, Cytoscape)
  • Own scripts/software
  • Repository: https://maxquant.org/maxquant/

Get in touch

Emanuela Oldoni

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