Microvesicles and the paracrine ‘omic.
Exosomes, macro and micro-vesicles released by mesenchymal cells represent a form of communication network which influence both healthy and diseased tissues. This was the main scientific message at the meeting on stem cells held in Padua last week.
Preliminary data in animal models show the transfer of the anti-inflammatory properties of the MSC using conditioned media. The use of vesicles from standardized sources will be next step toward a new class of medicinal products which may have strong advantages respect to the use of live cells. A strong initiative for the application in the clinic of this approach is now needed.