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Quality in Screening – EATRIS Webinar series (2/6)

Join event
Date & Time November 19 – 15:00 -16:00 CET
Location Webinar


  • Matthew Hall (NIH/NCATS)
  • Wolfgang Fecke (EU-OPENSCREEN)

Webinar Description

This webinar will focus on the need to develop standards and assays guidelines for high-throughput screening (HTS). It will highlight some initiatives such as the Assay Guidance Manual (AGM) ebook and the HTS ring-testing project both led by NIH-NCATS to mitigate irreproducibility rates in HTS. The second part of the webinar will give the floor to EU-OPENSCREEN, the infrastructure providing screening capacity in Europe. Dr Fecke will explain how quality is achieved across the infrastructure. An interactive Q&A session will conclude this 60-minute-webinar.


Reproducibility is a foundational element of the scientific method, a benchmark upon which the reliability of an experiment can be tested. However, the field is facing alarmingly high irreproducibility rates as illustrated in various industry publications, with reports ranging from 50% to 80% of published results not being reproducible. It has been estimated that in the US alone, $28B in funding is spent on preclinical research that is not reproducible. This estimation does not even consider the impact on delaying translational research and causing high failure rates observed for the development of new treatments. 

In this context, EATRIS will run a series of webinars this fall, looking at reproducibility issues experienced during specific phases of the drug development pipeline (screening, preclinical models, biomarker development & analytical platforms, clinical validation). The aim is to bring best practices together and to discuss solutions designed to tackle the identified bottlenecks. 

You will have the chance to get the latest updates from experts in the field as well as participate in a Q&A session at the end of the lecture. Please note that you will have the opportunity to watch again later as all webinars will be recorded.


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