EATRIS Combined Platform Meeting

Date & Time December 11 - 12th, 2018
Location Ljubljana, Slovenia

The 2018 EATRIS Combined Platform Meeting will be held in Ljubljana on December 11th and 12th. Like in previous years, the Platform Combined Meeting will be the moment to discuss the EATRIS platform activities and future strategies together, providing formidable networking opportunities. This year the Platform Combined Meeting will also be followed by a two-day CORBEL open workshop on the theme of public-private collaboration. This 2-day event on 12th and 13th December 2018 (back to back with the Combined EATRIS Platform meeting in Ljubljana) will focus on all relevant aspects of setting up such collaborations, from initial contacts through planning and negotiation to completion of legal agreements and project implementation.

We would very much welcome your contribution as a guest speaker at one of our break-out sessions as well as for posters. To submit your abstract, please follow this link until the 14th of October.

Provisional Schedule of the Combined Platform Meeting

 

Tuesday 11th December

09.30 – 12.30 Plenary session

Present and Future of EATRIS

12.30 – 13.30 Lunch

13.30 – 17.30 Break-out sessions

– A Multimodal approaches connecting Atoms to Anatomy*

 B Multimodal approaches for immunomodulation and immunomonitoring**

 C Multimodal approaches for patient stratification***

17.30 – 19.00 Networking drinks & Poster session

19.30 – 22.00 Networking dinner at the Grand Union Hotel restaurant

 

Wednesday 12th December

09.00 – 12.00 Plenary session

Feedback from the break-out sessions

EATRIS positioning & action agenda for the platforms

 12.00 – 13.00 Lunch

13.00 – 13.45 Plenary session

EATRIS implementation of operations at the national level

 13.45 – 14.00 Closing remarks

14.00 – 16.00 Strategy meeting (EATRIS National Directors and Platform Chairs only)

 

With regards to accommodation, we have reserved a block of rooms at the Grand Union Hotel at a discounted rate starting from 115€ per night. Reserve now your Business room (115€) or your Comfort room (135€).

Travel and accommodation reimbursement can be submitted after the meeting, up to 250€ for one person per platform per institution. The fund is limited and each submission is subject to review prior proceeding. To submit your reimbursement, please contact laureboudaud@eatris.eu before January 18th 2019.


 


*Multimodal approaches connecting Atoms to Anatomy

 An integrated understanding of mechanisms underlying disease phenomena can create new opportunities for therapeutic development. The modern translational research toolbox is maturing with multi-modal technologies that allow deep investigation of integrated biological systems and pathways rather than looking at isolated targets. For example, early clinical trials using whole body (multimodal) and functional imaging can provide key insights for target engagement, PK/PD or dosing to help predicting R&D success at early stage. In silico analysis, machine learning and artificial intelligence approaches may lead to new insights and hypotheses that can ultimately result in novel molecular tools and drug candidates. This session will cover emerging theranostic approaches where a deep molecular understanding of target modulation is combined with a novel systemic therapeutic strategy.

Through sharing case studies, we intend to define for EATRIS:

  • What is the current state of the art of theranostic approaches, within EATRIS and beyond
  • What are key determinants for the predictive value of a specific approach
  • How to achieve the highest translational potential for successful molecular intervention


**Multimodal approaches for Immunomodulation and Immunomonitoring

 Description: Immune Cell therapy represents a revolutionary treatment for hematological malignancies evidenced by the recent breakthrough successes involving CAR-T therapies for B-Cell Leukemias. The success of this type of treatment however has not yet been realized in solid tumors. One hypothesis is that the immunosuppressive nature of the tumor microenvironment (TME) influences and affects the efficacy of adoptive immunotherapy. Understanding the role of the TME and its interaction with immune cell therapies is key to improve the potency of adoptive immunotherapy. These include identifying multimodal approaches to monitoring the limited trafficking of adoptively transferred cells to tumor sites, the identification of proper tumor associated antigen and a greater understanding of the immunosuppressive effect of the tumor microenvironment. This session will discuss innovative multimodal approaches to immunomodulation and immunomonitoring to ensure the safest and most effective combinations of therapeutic modalities for patients with solid tumors.


***Multimodal approaches for patient stratification

Description: Development of biomarkers for patient stratification is a vital concept to facilitate the development and implementation of personalized medicines.

Multimodal biomarker approaches integrating various technologies (omics, imaging, functional readouts) are key in the development of high quality stratification biomarkers to enable personalized medicine diagnosis, prognosis and prediction of treatment effectiveness.

The session will highlight the current achievements and challenges in patient stratification biomarker R&D. Through sharing examples, we intend to define our best practice within EATRIS on the following key issues:

  • Technology push vs clinical pull
  • Approaches to combine multi-omics approaches
  • Quality, harmonization, standardization & reproducibility
  • Follow-up translation to product
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