Fundación Jiménez Díaz University Hospital Health Research Institute (IIS-FJD)

Address Avenida de los Reyes Católicos 2,
28040, Madrid,
Spain
Platforms Biomarkers

In addition to the hospital’s clinical and care-related activity, the Fundación Jiménez Díaz University Hospital Health Research Institute has an established record of commitment to research and teaching.

Health care, research, and teaching are the three pillars that guide the work carried out in the Institute, whose goal it is to drive excellence in research, scientific and technological understanding, and teaching and training. This mission informs the Institute’s strategy, striving to bring advancement and research to clinical practice in the most efficient way possible.

The Institute´s goal is to promote excellence in research, scientific and technological knowledge, and in-hospital teaching and training, helping to establish synergies and carry out integrated scientific study that brings together many top-level biomedical investigators by overcoming the traditional barriers. The Institute’s modern mindset and independent legal personality have given rise to a unique opportunity driven by high degrees of interdisciplinarity and a readiness to apply the tenets of translational medicine. Also, the recruitment of emerging researchers ensures the long-term future of the Institute.

The main objectives of the Institute are:

  • to promote quality biomedical research.
  • to provide scientific, administrative, and financial management for biomedical investigation.
  • to procure grants and other financial assistance for research projects, staff, and infrastructure.
  • to establish partnerships with universities, public or private institutions, and enterprises.
  • to increase the institution’s national and international prestige.
  • to transmit scientific progress and transfer the results of scientific work to increase societal awareness of research.
  • to support professional training for all research staff—researchers, clinicians, and support staff.

Mission

To develop an environment for scientific management and translational research that strives to solve problems affecting the national health system and to improve citizens’ quality of life. The Institute seeks to deliver measurable quality and excellence, allowing it to become a point of reference both nationally and internationally.

Transmit the knowledge acquired through research so as to properly train students of biomedicine at the undergraduate, graduate, and specialist stages, doing so in coordination with the university and with the relevant educational authorities.

Vision

To gain recognition from the various stakeholders (researchers, teaching staff, patients, clients, employees, and greater society) as a point of reference—an organization of excellence whose flexibility makes it a leader in quality services, in scientific output, in effective and efficient use of resources, and in the development of advanced management systems.

Values

Our values reflect the ethical grounding and the guiding principle for the Institute’s development:

  • Innovation.
  • Professionals.
  • Quality.
  • Transparency.
  • Human values.
  • Knowledge.
  • Client-orientedness.

Challenges for the future

The Institute has grown over recent years, propelled by the political will and management agenda of the different institutions that form part of the institution, thus turning the Institute into a center for biomedical excellence. Efforts to further this commitment will be made along different lines:

  • Adapt the available spaces of the Institute and increase equipment in order to expand scientific activity.
  • Create programs to increase knowledge development and transfer.
  • Promote clinical research.
  • Expand scientific, technical, and support services.
  • Transfer scientific knowledge to enterprise and foster its clinical application.
  • Make the Institute into an attractive setting for enterprises in the biomedical and biotechnology fields.

Institutes' Omics Technologies

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Contact

Facility Genetics
Head of the facility
  • Carmen Ayuso

Expertise

Technologies
  • SangerSequencing
  • NGS-Exome sequencing(WES)
  • NGS-other
  • Fluorescence in situ hybridization (FISH)
  • Array comparative genomic hybridization (aCGH)
  • Multiplex ligation-dependent probe amplification (MLPA)
  • Genotyping
  • qPCR
  • Droplet Digital PCR (ddPCR)
Purposes
  • Research
  • Clinical use
  • Service
Applications
  • Biomarkers discovery and development
  • Diagnostics and personalised disease profiling
  • Disease processes research
  • Epidemiology
  • Proteogenomic

Features

Collaboration with industry where the institute collaborated with Genomics expertise (in the last 5 years) >10
Certifications
  • ISO15189

Track record

Key opinion leaders
  • Carmen Ayuso, Lead in Human Genetics
  • Federico Rojo, Lead in Cancer Genetics
  • Sandra Zazo, Lead in Biomarkers
Publications

Contact

Facility Genetics
Head of the facility
  • Carmen Ayuso

Expertise

Technologies
  • DNA Methylation Analysis - High resolution melt (HRM)
  • DNA Methylation Analysis – DNA methylation arrays
  • Methylation-dependent restriction enzyme (MDRE) ChromatinAccessibilityandConformationAssays
Purposes
  • Research
  • Clinical use
Applications
  • Diagnostics and personalised disease profiling

Features

Collaboration with industry where the institute collaborated with Epigenomics expertise (in the last 5 years) <10

Track record

Key opinion leaders
  • Cristina Villaverde

Contact

Facility Proteomics and Metabolomics Platform
Head of the facility
  • Gloria Alvarez-Llamas

Expertise

Technologies
  • Western Blot
  • Isoelectric focusing (IEF)
  • ELISA
  • Luminex
  • LC-MS
  • Liquid chromatography (HPLC, UHPLC)
Purposes
  • Research
Applications
  • Biomarkers discovery and development
  • Disease processes research

Features

Collaboration with industry where the institute collaborated with Proteomics expertise (in the last 5 years) <10

Track record

Key opinion leaders
  • Gloria Alvarez-Llamas
Publications

Contact

Facility Proteomics and Metabolomics Platform
Head of the facility
  • Gloria Alvarez-Llamas

Expertise

Technologies
  • High performance liquid chromatography (HPLC,UHPLC)
  • LC-MS
Purposes
  • Research
Applications
  • Biomarkers discovery and development
  • Disease processes research

Features

% of TIME involved in technology/methods development/innovation/intellectual property related to Metabolomics <10

Track record

Publications

DATA ANALYSIS for

  • Genomics
  • Omics data integration/systems biology

DATA INTERPRETATION for

  • Genomics
  • Omics data integration/systems biology

DATA SUBMISSION in to public database

STATISTICS

  • Molecular profiling (omics and others)
  • Expertise in clinical design of experiments, clinical statistics
  • Metadata (patient/sample information)

BIOINFORMATICS

  • Expression profiling with omics and microarrays for RNAseq, microRNA, other RNA species
  • Methylation profiling with NGS
  • Data integration (“Systems biology”)
  • Genetic analysis for Structural variation detection (Genome, Exome) and prediction of protein function from sequence information
  • Development of new algorithms, e.g. new decision algorithms, new sequence aligners for NGS data, etc.
  • Informatics methods to support clinical decisions (diagnostic, predictive tests)

OMICS INTEGRATION METHODS

  • Own scripts/software